@MASTERSTHESIS{ 2018:153196501,
 	title = {Predictive markers of oxidative stress and diagnostic metabolomic signatures in patients with chronic kidney disease},
 	year = {2018},
 	url = "https://bdtd.unifal-mg.edu.br:8443/handle/tede/1228",
 	abstract = "The prevalence of chronic kidney disease (CKD) and patients in hemodialysis (HD) is increasing wordwide. Currently, adequate management of CKD presents many challenges, especially early diagnosis and treatment, which are essential to attenuate the decline of renal function, as well as to prevent the establishment and progression of CKD-related diseases. CKD is accompanied by intense metabolic changes, which result in accumulation of uremic metabolites associated with systemic toxicity. From a strict restriction on food intake to reduce the accumulation of proinflammatory uremic toxins, severe nutritional deficiency and imbalance of redox metabolism are more a rule than exception in CKD patients. Thus, we evaluated the association between body composition, nutritional status, food intake, antioxidant defenses, lipid and protein oxidation in HD patients. Our findings indicated that the combination of anthropometric, nutritional and biochemical measures is useful to assess malnutrition in HD patients. Furthermore, we identifyed that carbohydrate and zinc dietary intake, zinc serum levels, glutathione peroxidase activity, total antioxidant capacity and non-protein antioxidants in serum were predictive markers of lipid and protein oxidation. Besides the markers of oxidative stress in CKD patients are poorly understood, to identify new diagnostic markers of end-stage renal disease is also necessary and urgent. Thus, we used an integrated model based on systematic review, analysis of dynamic networks and multivariate statistics to addictionaly investigates metabolomic signatures in different populational groups with CKD. From targeted and untargeted metabolomic studies, to identify bimarkers usefull as molecular predictors of CKD was the focus of research. By analyse data from 4763 Asian, European and North American patients, our findings indicated that protein metabolism was the metabolic patway most affected in CKD. Furthermore, from 233 metabolites with well-defined behaviors in plasma and urine identified in individual studies, only the increased kinurenine and p-cresol sulphate plasma levels obtained acceptable scores as biomarkers of CKD, regardless of geographic origin. Taken together, our studies showed that there is a relationship of oxidative stress, nutrient intake and nutritional status in CKD patients; and that at despite the highly variable metabolomic signatures in plasma and urine, these patients can exhibit molecular similarities potentially useful as diagnostic markers of CKD",
 	publisher = {Universidade Federal de Alfenas},
 	scholl = {Programa de Pós-Graduação em Biociências Aplicada à Saúde},
 	note = {Instituto de Ciências Biomédicas}
}